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EACH VIAL CONTAINS 40 MG OF DIGOXIN IMMUNE DIGIFAB IS A STERILE, LYOPHILIZED PREPARATION OF DIGOXIN-IMMUNE OVINE FAB (MONOVALENT) IMMUNOGLOBULIN FRAGMENTS. THESE FRAGMENTS ARE OBTAINED FROM THE BLOOD OF HEALTHY SHEEP IMMUNIZED WITH A DIGOXIN DERIVATIVE, DIGOXIN DICARBOXYMETHOXYLAMINE (DDMA), A DIGOXIN ANALOGUE WHICH CONTAINS THE FUNCTIONALLY ESSENTIAL CYCLOPENTAPERHYDROPHENANTHRENE: LACTONE RING MOIETY COUPLED TO KEYHOLE LIMPET HEMOCYANIN (KLH). THE FINAL PRODUCT IS PREPARED BY ISOLATING THE IMMUNOGLOBULIN FRACTION OF THE OVINE SERUM, DIGESTING IT WITH PAPAIN AND ISOLATING THE DIGOXIN-SPECIFIC FAB FRAGMENTS BY AFFINITY CHROMATOGRAPHY

A STERILE NONPYROGENIC, PURIFIED, LYOPHILIZED PREPARATION OF OVINE FAB (MONOVALENT) IMMUNOGLOBULIN FRAGMENTS OBTAINED FROM THE BLOOD OF HEALTHY SHEEP FLOCKS IMMUNIZED WITH ONE OF THE FOLLOWING NORTH AMERICAN SNAKE VENOMS. (WESTERN DIAMONDBACK RATTLESNAKE, EASTERN DIAMONDBACK RATTLESNAKE, MOJAVE RATTLESNAKE OR WATER MOCCASIN). TO OBTAIN THE FINAL ANTIVENIN PRODUCT, THE FOUR DIFFERENT MONOSPECIFIC ANTIVENINS ARE MIXED. EACH MONOSPECIFIC ANTIVENIN IS PREPARED BY FRACTIONATING THE IMMUNOGLOBULIN FROM THE OVINE SERUM, DIGESTING IT WITH PAPAIN AND ISOLATING THE VENOM SPECIFIC FAB FRAGMENTS ON ION EXCHANGE AND AFFINITY CHROMATOGRAPHY COLUMNS. EACH VIAL CONTAINS UP TO 1G OF TOTAL PROTEIN AND NOT LESS THAN THE INDICATED NUMBER OF MOUSE LD50 NEUTRALIZING UNITS PER VIAL. USED FOR THE MANAGEMENT OF PATIENTS WITH NORTH AMERICAN CROTALID ENVENOMATION.

RABBIT POLYCLONAL ANTIBODY TO GFP. WHOLE ANTISERUM WITH SODIUM CHLORIDE (1.25%) AND SODIUM AZIDE (0.05%) AS PRESERVATIVE. THE PRODUCT WAS MADE BY INJECTING AN IMMUNOGEN CONSISTING OF A FULL LENGTH RECOMBINANT GFP PROTEIN INTO A RABBIT. FOLLOWING AN IMMUNE RESPONSE ANTI SERUM WAS EXTRACTED FROM THE BLOOD OF THE ANIMAL. THE PRODUCT IS PRESENTED IN A 0.5 ML SCREW TOP TUBE FOR IN VITRO RESEARCH USE

RABBIT POLYCLONAL ANTIBODY TO GFP. PURIFIED 1GG SUPPLIED AT 0.5 MG/ML BUFFER CONTAINING GLYCEROL AND TRIS HCL TO PH 7.4. THE PRODUCT IS MADE BY INJECTING A RECOMBINANT GFP PROTEIN IMMUNOGEN INTO A RABBIT WHICH PROVOKES AN IMMUNE RESPONSE. ANTISERUM IS THEN EXTRACTED FROM THE BLOOD OF THE ANIMAL AND PURIFIED ON AN AFFINITY CHROMATOTOGRAPHY COLUMN MADE WITH HIGHLY PURIFIED RECOMBINANT GFP. THE PRODUCT IS PRESENTED IN A 0.5ML SCREW TOP TUBE FOR IN VITRO RESEARCH USE.

MONOCLONAL ANTIBODIES PRODUCED BY CONTINUOUS PERFUSION FERMENTATION OF MAMMALIAN CELL CULTURES AND PURIFIED BY CHEMICAL AND PHYSCIAL TECHNIQUES.