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Urea CAS# 57-13-6 Application: Pharmaceutical Containing more than 45% by weight of nitrogen on the dry anhydrous product. State: Solid Colour: White crystal Odour: Ammonia Like

UREA. CONTAINING MORE THAN 45% BY WEIGHT OF NITROGEN ON THE DRY ANHYDROUS PRODUCT. CAS# 57-13-6 CUS: 0025078-2 STATE: SOLID COLOUR: WHITE CRYSTAL ODOUR: AMMONIA-LIKE

UREA CRYSTAL. NOTROGEN CONTENT IS 46.7%

EACH VIAL CONTAINS 40 MG OF DIGOXIN IMMUNE DIGIFAB IS A STERILE, LYOPHILIZED PREPARATION OF DIGOXIN-IMMUNE OVINE FAB (MONOVALENT) IMMUNOGLOBULIN FRAGMENTS. THESE FRAGMENTS ARE OBTAINED FROM THE BLOOD OF HEALTHY SHEEP IMMUNIZED WITH A DIGOXIN DERIVATIVE, DIGOXIN DICARBOXYMETHOXYLAMINE (DDMA), A DIGOXIN ANALOGUE WHICH CONTAINS THE FUNCTIONALLY ESSENTIAL CYCLOPENTAPERHYDROPHENANTHRENE: LACTONE RING MOIETY COUPLED TO KEYHOLE LIMPET HEMOCYANIN (KLH). THE FINAL PRODUCT IS PREPARED BY ISOLATING THE IMMUNOGLOBULIN FRACTION OF THE OVINE SERUM, DIGESTING IT WITH PAPAIN AND ISOLATING THE DIGOXIN-SPECIFIC FAB FRAGMENTS BY AFFINITY CHROMATOGRAPHY

A STERILE NONPYROGENIC, PURIFIED, LYOPHILIZED PREPARATION OF OVINE FAB (MONOVALENT) IMMUNOGLOBULIN FRAGMENTS OBTAINED FROM THE BLOOD OF HEALTHY SHEEP FLOCKS IMMUNIZED WITH ONE OF THE FOLLOWING NORTH AMERICAN SNAKE VENOMS. (WESTERN DIAMONDBACK RATTLESNAKE, EASTERN DIAMONDBACK RATTLESNAKE, MOJAVE RATTLESNAKE OR WATER MOCCASIN). TO OBTAIN THE FINAL ANTIVENIN PRODUCT, THE FOUR DIFFERENT MONOSPECIFIC ANTIVENINS ARE MIXED. EACH MONOSPECIFIC ANTIVENIN IS PREPARED BY FRACTIONATING THE IMMUNOGLOBULIN FROM THE OVINE SERUM, DIGESTING IT WITH PAPAIN AND ISOLATING THE VENOM SPECIFIC FAB FRAGMENTS ON ION EXCHANGE AND AFFINITY CHROMATOGRAPHY COLUMNS. EACH VIAL CONTAINS UP TO 1G OF TOTAL PROTEIN AND NOT LESS THAN THE INDICATED NUMBER OF MOUSE LD50 NEUTRALIZING UNITS PER VIAL. USED FOR THE MANAGEMENT OF PATIENTS WITH NORTH AMERICAN CROTALID ENVENOMATION.